Brock Purdy’s Career-High 5 TD Passes Propel 49ers to Dominant 48-27 Victory Over Colts
INDIANAPOLIS — San Francisco 49ers quarterback Brock Purdy delivered a career-defining performance on Monday Night Football, throwing **five touchdown passes** to lead his team to a resounding 48-27 win over the Indianapolis Colts at Lucas Oil Stadium. The victory improved the 49ers to 11-4 on the season, marking their fifth straight win and solidifying their position in the race for the NFC’s No. 1 seed.[1][2]
Purdy completed 25 of 34 passes for 295 yards, with five touchdowns and one interception, shattering previous personal benchmarks and etching his name into 49ers history. This was the first five-touchdown game of his career and the first time a San Francisco quarterback achieved that feat on a Monday night, joining legends like Steve Young, who last did so in Super Bowl XXIX.[1]
Purdy Overcomes Monday Night Struggles
Entering the game, Purdy had faced criticism for his performances on the primetime stage, posting just five touchdowns against 11 interceptions in his previous five Monday night outings, where the 49ers went 2-3.[1] Purdy himself acknowledged post-game that he had a history of pressing in high-pressure spots, referencing a four-interception debacle against the Baltimore Ravens on Christmas night in 2023. “I’ve grown since then,” he said, crediting improved execution.[1]
Against an injury-depleted Colts secondary, Purdy excelled on deep throws, going 12-of-16 for 213 yards and two touchdowns on passes of 10-plus yards downfield. His season-high 9.4 air yards per attempt underscored a newfound precision and aggression early in the season he had struggled with, where he had only two such touchdowns against six picks.[1]
Key Moments Seal the Blowout
The game was a back-and-forth affair early on. Purdy broke a tie with an 11-yard touchdown pass to tight end George Kittle, giving San Francisco a lead they wouldn’t relinquish. The teams traded field goals before Colts kicker Eddie Pineiro’s 64-yard attempt clanged off the crossbar as time expired in the first half, leaving the 49ers up 24-17.[2]
The second half belonged to San Francisco. Purdy capped the opening drive with a 15-yard touchdown to wide receiver Jauan Jennings, extending the lead to 31-17. Colts running back Jonathan Taylor answered with a 1-yard touchdown run early in the fourth, trimming the deficit to 34-27. But Purdy responded with a 9-yard scoring strike to running back Christian McCaffrey with 7:37 remaining.[2]
The dagger came with 3:26 left when linebacker Dee Winters intercepted a final pass from 44-year-old Colts quarterback Philip Rivers — in what may have been a comeback spotlight moment — and returned it 74 yards for a touchdown, sealing the 48-27 final.[2] “It was cool to be out here playing against Philip Rivers and the Colts,” Purdy said. “To go out and execute like we did, I’m really proud of these guys.”[2]
49ers Offense Hits Stride Ahead of Playoffs
Coming off a playoff-clinching weekend, the 49ers’ offense fired on all cylinders, showcasing the firepower needed for a deep postseason run. Purdy’s elite-level operation, combined with defensive plays like Winters’ pick-six, highlighted San Francisco’s balance. The win not only avenged past Monday night demons but positioned the Niners for home-field advantage throughout the NFC playoffs.[1][2]
Highlights from Purdy’s night, including his best plays, have already gone viral, with official 49ers footage capturing the five touchdown tosses that dismantled Indianapolis.[3] Analysts noted the blowout as a statement, with Purdy and the offense operating at peak efficiency.[4]
Playoff Implications and Looking Ahead
With the victory, San Francisco now sits at 11-4, riding a five-game winning streak into the crucial final weeks.[2] The Colts, meanwhile, slip further from contention, their hopes dimmed by Rivers’ late interception in a game that pitted veteran savvy against emerging stardom.
Purdy’s growth from Mr. Irrelevant — the last pick of the 2022 NFL Draft — to playoff-contending signal-caller continues to captivate. This performance silences doubters and signals the 49ers are peaking at the perfect time. As the regular season winds down, all eyes remain on San Francisco’s pursuit of NFC supremacy.