Week 5 College Football Preview: Moneyline Underdogs Highlight Key Matchups
As the 2025 college football season intensifies, two exciting matchups stand out for bettors eyeing moneyline underdogs: the Washington Huskies versus the Ohio State Buckeyes, and Iowa State facing off against the Arizona Wildcats. These games are set to offer intriguing betting opportunities and on-field drama.
Washington Huskies at Ohio State Buckeyes
The No. 1 ranked Ohio State Buckeyes (3-0) are set to host the Washington Huskies (3-0) at Alaska Airlines Field at Husky Stadium in Seattle on Saturday, September 27, 2025, at 3:30 p.m. ET. Ohio State enters the game as clear favorites, with the latest odds placing them as 8.5-point favorites and a moneyline of approximately -325. Washington, meanwhile, is the underdog with a moneyline of +260.
The Buckeyes have been dominant this season, most recently dismantling the Ohio Bobcats 37-9, showcasing a strong offense and reliable defense. Conversely, Washington demonstrated a prolific scoring ability in their last outing, a 59-24 victory over conference rival Washington State. Although Washington will be playing on their home turf, the consensus among oddsmakers and analysts leans heavily towards Ohio State continuing their undefeated streak.
Experts suggest the total points for the game hover around 52.5, with some models leaning towards the ‘under’ at approximately 49 combined points scored. SportsLine’s advanced predictive model indicates one side of the spread hits nearly 60% of the time and is highlighting Ohio State, but Washington’s +260 moneyline remains tempting for bettors seeking an underdog payout.
Iowa State Cyclones vs. Arizona Wildcats
While fewer details are immediately available for the Iowa State vs. Arizona matchup, early betting lines designate Iowa State as a potential underdog in this non-conference battle. Bettors often look to these games for sharp moneyline payouts and potential upset picks, especially considering the volatility early in the college football season.
Moneyline Underdog Picks for Week 5
- Washington Huskies +260 against Ohio State—a high-ranked contender on the road with strong recent offensive performances.
- Iowa State Cyclones as underdogs against Arizona—with potential for an upset based on momentum and matchup advantages.
What to Watch
Ohio State’s offense is led by efficient passing and a powerful running game, making them a tough team to beat. However, Washington’s ability to score in bunches suggests the Huskies may keep the game competitive, possibly providing value to those betting on the underdog moneyline.
For Iowa State and Arizona, recent form, key injuries, and coaching strategies will be crucial in determining the result, with both programs eager to prove their mettle in this pivotal Week 5.
Broadcast and Viewing
The Ohio State vs. Washington game will be televised nationally on CBS, allowing fans across the country to tune in to what promises to be an engaging contest. Betting markets will continue to evolve leading up to kickoff as more information emerges on lineups and conditions.
College football enthusiasts and bettors should monitor injury reports, starting lineups, and expert analyses closely. Balancing risk and reward with underdog moneylines like Washington’s could be a lucrative strategy heading into this weekend’s contests.